2022 PRECEDE Annual Meeting and Biomarker Summit

DECEMBER 7-8, 2022

CORNELL TECH VERIZON CENTER

2 W LOOP RD, ROOSEVELT ISLAND, NEW YORK, NY

Live Virtual Streaming Available (see below)

DAY 1. WEDNESDAY, DECEMBER 7TH ▪ PRECEDE ANNUAL MEETING

8:00-9:00 AM Breakfast / Registration / Networking
9:00-9:15 AM Welcoming Remarks and Updates – Diane Simeone, MD, Chair, PRECEDE Steering Committee, PI of PRECEDE Consortium Study (NYU Langone)
9:15-9:30 AM Update on PRECEDE Enrollment, Website, and IRB – John Graff, PhD (Arbor Research)
9:30-11:00 AM PRECEDE Committee Updates – Moderated by Diane Simeone, MD

Ancillary studies committee – James Farrell, MD (Yale) and Jens Siveke, MD (Essen)

Biomarkers/biosamples committee – Aatur Singhi, MD, PhD (UPMC) and Julie Earl, PhD (Ramon y Cajal)

Clinical genetics committee – Aimee Lucas, MD (Mt. Sinai) and Fay Kastrinos, MD (Columbia Univ.)

DEI committee – Sonia Kupfer, MD (Univ. Chicago) and Nipun Merchant, MD (Univ. Miami)

Genomics committee – George Zogopoulos MD, PhD (McGill Univ.) and Giovanni Parmigiani, PhD (Harvard)

• Imaging committee – Alexander Guimaraes, MD, PhD (OHSU) and Chenchan Huang, MD (NYU)

Publications committee – Bryson Katona, MD, PhD (Univ. of Penn) and Kelsey Klute, MD (UNMC)

11:00-11:15 AM Break
11:15-12:15 PM PRECEDE Projects Updates – Moderated by Bryson Katona, MD, PhD

HRV and Accelerometry – Aaron Grossberg, MD, PhD (OHSU)

• Update on the GPS Study – Rachid Karam, MD, PhD (Ambry Genetics)

RNA testing using PRECEDE panel – Randy Brand, MD (Univ. of Pittsburgh)

Pancreatic imaging findings in PRECEDE – Ido Haimi, MD (NYU Langone)

Discussion

12:15-1:00 PM Lunch
1:00-1:20 PM Long molecule footprints of backup DNA repair pathways in homologous recombination deficient cancers – Marcin Imielinski, MD, PhD (NY Genome Center)
1:20-1:40 PM Insights into PDAC development using 3D mapping – Laura Delong Wood, MD, PhD (Johns Hopkins University)
1:40-2:20 PM Pancreatic cancer surveillance in mutation carriers without a family history of PDAC

Moderated by Aimee Lucas, MD (Icahn School of Medicine at Mt. Sinai)

• 1:45-2:00PM For – Talia Golan, MD (Sheba Medical Center)

• 2:00-2:10PM Against – Randall Brand, MD (Univ. of Pittsburgh)

• 2:10-2:20PM Panel Discussion

2:20-3:00 PM Pancreatic cancer surveillance disparities
Moderated by Sonia Kupfer, MD (University of Chicago)
• 2:25-2:35PM

  • Disparities in high-risk patients undergoing pancreatic surveillance:
    Observations from PRECEDE – Bryson Katona, MD, PhD (U. Penn)

• 2:35-2:45PM

  • Pancreatic Cancer and Health Disparities in the Black Community Darwin Conwell, MD, MSc (Univ. of Kentucky)

• 2:45-2:55PM

  • Community Engagement Strategies – Victoria Foster, MPH (NYU)

• 2:55-3:05PM

  • Panel Discussion
3:05-3:35 PM Break
3:35-4:35 PM Special Panel – Moderated by Kate Bolduan, CNN Anchor
4:35-4:45 PM Wrap up and closing remarks
5:00-6:00 PM PRECEDE Cocktails – The Cornell Tech Verizon Center, 2nd Fl.
6:00-8:30 PM PRECEDE Dinner & DJ  (author William Schwalbe-invited comments)The Cornell Tech Verizon Center, 1st Fl.

DAY 2. THURSDAY, DECEMBER 8TH ▪ PRECEDE BIOMARKER SUMMIT

7:30-8:30 AM Breakfast / Networking
8:30-8:45 AM Opening Remarks – Diane Simeone, MD, Chair, PRECEDE Steering Committee, Professor of Surgery and Pathology, NYU Langone Health
8:45-9:00 AM Current State of Early Detection Biomarkers for Pancreatic Cancer – Rosie Sears, PhD Professor, Dept. of Molecular and Medical Genetics, OHSU
9:00-9:20 AM Precision Oncology in Pancreatic Cancer: Genetics Matter – Kim A. Reiss, MD Assistant Professor of Medicine, University of Pennsylvania
9:20-9:30 AM Questions – Moderated by Rosie Sears, PhD and Kim A. Reiss, MD
9:30-11:30 AM PANEL: BIOMARKERS FOR EARLY DETECTION OF PANCREATIC CANCER

Moderated by Andrew Lowy, MD, Chief of Surgical Oncology, UCSD

NIH and FDA PERSPECTIVES

9:30-9:50 AM Biomarkers and Probe Design – Sudhir Srivastava, PhD MPH, Chief, Cancer Biomarkers Research Group, NIH
9:50-10:10 AM Delineating the FDA Process for Approval of Blood-based Biomarkers – Anand Pathak, MD PhD, Senior Medical Officer of Biomarkers and Precision Oncology, FDA

INDUSTRY PERSPECTIVES ON PANCREAS-SPECIFIC VS. MULTI-CANCER TESTS

10:10-10:20 AM Immunovia, Thomas King, MD, PhD – Medical Director (Virtual)
10:20-10:30 AM Biological Dynamics, Harmeet Dhani, MD, MSc – Medical Director
10:30-10:40 AM Bluestar Genomics, Samuel Levy, PhD – Chief Scientific Officer
10:40-10:50 AM Micronoma, Gregory Poore, PhD – Co-founder, Chief Analytics Officer
10:50-11:00 AM Grail, Jeff Venstrom, MD – Chief Medical Officer
11:00-11:10 AM Guardant Health, Sven Duenwald – VP Screening Technology Development (Virtual)
11:10-11:30 AM Discussion
11:30-12:30 PM Lunch
12:30-1:30 PM PANEL: IMAGING MODALITIES FOR EARLY DECTECTION OF PANCREATIC CANCER

Moderated by Alexander Guimaraes, MD, PhD, Professor of Diagnostic Radiology, School of Medicine OHSU and Ilya Gipp, MD, PhD Medical Officer of Oncology, Philips

12:30-12:50 PM Molecular Imaging – Ken Herrmann, MD, MBA, Chair Nuclear Medicine, University Hospital Essen (Virtual)
12:50-1:10 PM MRI and Radiomics-based Machine Learning – Hersh Chandarana, MD, Professor of Radiology and Urology at NYU Grossman School of Medicine
1:10-1:45 PM Advances in AI and Multi-Omics and Data Integration; Update on LATTICE Project Tom Schoenherr, CEO of Ambry Genetics, REALM IDx; Donavan Cheng, PhD, Vice President of Analytics & Omics, REALM IDx
1:45-2:00 PM Discussion
2:00-2:35 PM Break
2:35-2:55 PM Setting the Stage: Building the Roadmap for Public/Private Partnerships for Early Pancreatic Cancer Detection Paul Kurywchak, PhD, Executive Director at Skipper Bio Med
2:55-3:10 PM Overview of PRECEDE Data and Biosamples – Diane Simeone, MD, Chair, PRECEDE Steering Committee, Professor of Surgery and Pathology, NYU Langone Health
3:10-4:30 PM PANEL: CAN WE DEVELOP A ROADMAP TOGETHER? Moderated by Ilya Gipp, MD, PhD Medical Officer of Oncology, Philips; Andrew Lowy, MD, Chief of Surgical Oncology, UCSD

Academic Perspective: Diane Simeone, MD, NYU Langone; Giovanni Parmigiani, PhD, Harvard

Industry Perspective: Tom Schoenherr CEO at Ambry Genetics; Rebecca Leary, PhD, Director, Next Generation Diagnostics, Oncology Translational Research, Novartis Institutes for BioMedical Research; Subha Madhavan, PhD, VP & Head Clinical AI/ML Early Clinical Development at Pfizer

Non-Profit Perspective: Paul Kurywchak, PhD, Executive Director at Skipper Bio Med; Doug Frankel, TrovaNow; Garry Lowe, Vice Chair, the John Robert Lewis Legacy Institute

4:30-4:45 PM Wrap-up and Closing Remarks
5:00-6:30 PM Cocktails and Networking – The Cornell Tech Verizon Center, 2nd Fl.

Live Virtual Streaming Available

Zoom Meeting ID: 891 6494 2019

Passcode: 562200

Join from a PC or smartphone

https://us06web.zoom.us/j/89164942019?pwd=Z2VzQXlMbDlmTzZLU0d2ZzNEQnVVQT09

SPEAKERS

Picture Name Institution Linkedin Page Academic/Industry Website
Diane Simeone NYU Langone Health https://www.linkedin.com/in/diane-m-simeone-964b35163/ https://nyulangone.org/doctors/1215038138/diane-m-simeone
John Graff Arbor Research https://www.arborresearch.org/Our-Team
James Farrell Yale Medicine https://www.linkedin.com/in/james-farrell-278bb511/ https://medicine.yale.edu/profile/james_j_farrell/
Jens Siveke University Hospital Essen https://dktk.dkfz.de/en/research/dktk-researchers/siveke-group
Aatur Singhi University of Pittsburgh https://www.linkedin.com/in/aatur-singhi-5a6a0571/ https://path.upmc.edu/personnel/Faculty/singhi.htm
Julie Earl Hospital Universitario Ramon y Cajal, Ramón y Cajal Health Research Institute (IRYCIS) https://www.linkedin.com/in/julie-earl-04379523/?originalSubdomain=es http://vision.sav.sk/i_lectures/earl_cv.pdf
Aimee Lucas Mount Sinai https://www.linkedin.com/in/aimee-lucas-8095216a/ https://profiles.mountsinai.org/aimee-lucas
Fay Kastrinos Columbia https://www.cancer.columbia.edu/profile/fay-kastrinos-md
Sonia Kupfer University of Chicago Medicine https://www.linkedin.com/in/kupfer-sonia-5a7a958b/ https://www.uchicagomedicine.org/find-a-physician/physician/sonia-kupfer
Nipun Merchant University of Miami https://umiamihealth.org/sylvester-comprehensive-cancer-center/research/faculty/nipun-b-merchant-md
George Zogopoulos McGill https://www.mcgill.ca/generalsurgery/george-zogopoulos
Giovanni Parmigiani Harvard https://www.linkedin.com/in/giovanni-parmigiani-024a11b/ https://www.hsph.harvard.edu/giovanni-parmigiani/
Alexander Guimaraes OHSU https://www.ohsu.edu/people/alexander-guimaraes-md-phd-facr
Bryson Katona PennMedicine https://www.linkedin.com/in/bryson-katona-6127861b9/ https://grail.com/who-we-are/?module=company-staff
Kelsey Klute UNMC https://www.linkedin.com/in/kelsey-klute-42a796a1/ https://www.unmc.edu/intmed/divisions/onchem/faculty/klute.html
Aaron Grossberg OHSU https://www.linkedin.com/in/aaron-grossberg-36775444/ https://www.ohsu.edu/people/aaron-grossberg-md-phd
Rachid Karam Ambry Genetics https://www.linkedin.com/in/rachidkaram/ https://www.ambrygen.com/providers/webinar/80/rna-seq-as-a-complement-to-dna-genetic-testing-with-rachid-karam-md-phd"
Randy Brand University of Pittsburgh https://profiles.dom.pitt.edu/faculty_info.aspx/Brand5626"
Ido Haimi NYU Langone Health https://www.linkedin.com/in/ido-haimi-666640214/
Marcin Imielinski NY Genome Center https://www.linkedin.com/in/marcin-imielinski-m-d-ph-d-67789518/ https://www.nygenome.org/people/marcin-imielinski-md-phd/
Laura Delong Wood Johns Hopkins https://www.hopkinsmedicine.org/profiles/details/laura-wood
Talia Golan Sheba Medical Center https://www.shebaonline.org/doctors/talia-golan/
Darwin Conwell National Pancreas Foundation https://www.linkedin.com/in/drdarwinconwell/ https://pancreasfoundation.org/darwin-conwell/
Victoria Foster NYU Langone Health https://www.linkedin.com/in/victoria-foster-62127a41/
Rosie Sears OHSU https://www.linkedin.com/in/rosalie-sears-270b638/ https://www.ohsu.edu/people/rosalie-c-sears-phd
Kim A. Reiss PennMedicine https://www.med.upenn.edu/apps/faculty/index.php/g348/p6482784
Andrew Lowy UC San Diego Health https://providers.ucsd.edu/details/12065/surgery-cancer
Sudhir Srivastava NIH https://prevention.cancer.gov/about-dcp/staff-search/sudhir-srivastava-phd-mph
Anand Pathak FDA https://www.linkedin.com/in/anand-pathak-md-phd-mph-b64810a/
Thomas King Immunovia, Inc https://www.linkedin.com/in/thomas-king-881823bb/ https://immunovia.com/staff/tom-king/
Harmeet Dhani Biological Dynamics https://www.linkedin.com/in/harmeetdhani/ https://biologicaldynamics.com/
Samuel Levy Bluestar Genomics https://www.linkedin.com/in/samuel-levy-6ab1021/ https://past.pmwcintl.com/samuel-levy-2019sv/
Jeff Venstrom Grail https://www.linkedin.com/in/jeffrey-venstrom/ https://grail.com/who-we-are/?module=company-staff
Sven Duenwald Guardant Health https://www.linkedin.com/in/sven-duenwald-9128a71/ https://guardanthealth.com
Ilya Gipp Philips https://www.linkedin.com/in/ilyagipp/ https://grandroundsinurology.com/author/igipp/
Ken Herrmann University Hospital Essen https://www.linkedin.com/in/ken-herrmann-7a0630231/ https://sofie.com/team/ken-herrmann/
Hersh Chandarana NYU Langone Health https://www.linkedin.com/in/hersh-chandarana-20a98731/ https://nyulangone.org/doctors/1558528455/hersh-chandarana
Tom Schoenherr Ambry Genetics, REALM IDx https://www.linkedin.com/in/tom-schoenherr-06858733/ https://www.ambrygen.com/company/our-people
Donavan Cheng REALM IDx https://www.linkedin.com/in/donavancheng/
Subha Madhavan Pfizer https://www.linkedin.com/in/subhamadhavan/ https://icbi.georgetown.edu/madhavan/
Craig Tendler Janssen https://www.linkedin.com/in/craig-tendler-543b293/ https://www.ceoroundtableoncancer.org/leadership-team/craig-l-tendler-md
Paul Kurywchak Skipper BioMed https://www.linkedin.com/in/paul-a-kurywchak-phd-44a66854/ https://www.skipperbiomed.com/who-we-are/
Chenchan Huang NYU Langone Health https://nyulangone.org/doctors/1023336732/chenchan-huang
Kate Bolduan CNN News Anchor https://www.linkedin.com/in/kate-bolduan-775a741b5/ https://www.cnn.com/profiles/kate-bolduan-profile
Garry Lowe The John Robert Lewis Legacy Institute https://www.johnrlewisinstitute.org/about-jrlli
Gregory Poore Micronoma https://www.linkedin.com/in/greg-poore/ https://www.micronoma.com/micronoma-team/
William Schwalbe Author, Entrepreneur and Journalist https://www.linkedin.com/in/will-schwalbe-2430547/ https://willschwalbe.com/about/
Doug Frankel TrovaNow, National Search Associates https://www.linkedin.com/in/dougfrankel/ https://nsasearch.com/doug-frankel/
Rebecca Leary Novartis https://www.linkedin.com/in/rebecca-j-leary/ https://www.novartis.com/careers/postdoc-program/postdoc-research-themes/cancer-biology-postdoc-mentors/rebecca-leary-phd

Accommodations and Transportation

Hotels

The Graduate Hotel on Roosevelt Island  – located next door to the meeting site – Cornell Tech/Verizon Center

https://www.graduatehotels.com/roosevelt-island/

The Bentley Hotel – located at 500 East 62nd Street

https://www.bentleyhotelnyc.com/

https://goo.gl/maps/ju4gNhNupUCnitVu6

Shuttle bus will be provided from the Bentley  to the Cornell/Tech Verizon Center and return to the Bentley.

  • Pick up at 7:30 am in the lobby on Wednesday, December 7th.
  • Pick up at 7:00 am in the lobby on Thursday, December 8th.
  • Shuttle will depart the meeting from Cornell Tech/Verizon Center at 9:00 pm on Wednesday, December 7th
  • Shuttle will depart the meeting from the Cornell Tech/Verizon Center at 7:00 pm on Thursday, December 8th

Please contact inquire in the lobby if you have any questions or issues related to the shuttle service on the day of the event.

Public Transportation

BY SUBWAY

From Manhattan or Queens, take the F Train to the Roosevelt Island stop

Cornell Tech Campus is a 4-5min walk south from the Roosevelt Island Station

After exiting the subway station, head southwest on West Road towards West Main Street

Continue Straight on West Main Steet

Once you reach North Loop Road, Cornell Tech Campus will be directly infront of you.

BY TRAM

From Manhattan, take the Tramway Car at 59th Street & Second Avenue Station.

Exit at tramway station on Roosevelt Island.

Cornell Tech Campus is a 3min walk from the Roosevelt Island Tramway

After exiting the tramway, head west on West Main Street towards Manhattan

Turn left to stay on West Main Street

Once you reach North Loop Road, Cornell Tech Campus will be directly infront of you.

Cornell Tech Campus is a 3min walk from the Roosevelt Island Tramway where the RIOC Red Shuttle ends

After exiting the tramway, head west on West Main Street towards Manhattan

Turn left to stay on West Main Street

Once you reach North Loop Road, Cornell Tech Campus will be directly infront of you.

*For more information, visit: https://rioc.ny.gov/tramtransportation.htm

BY FERRY

From Manhattan, board at either Wall St/Pier 11 or East 34th St, at FDR Drive toward Astoria.

The travel time from Wall St and East 34th St is 35 and 20 minutes, respectively.

After exiting the ferry, head South on East Main Street. Make a right onto North Loop Road, and Cornell Tech Campus will be on your left.

*For further information regarding ferry schedule, visit: https://www.ferry.nyc/routes-and-schedules/route/astoria/

From Queens, board the ferry at either the Astoria landing at 3-10 Astoria Blvd toward Wall Street, or at the Long Island City landing at 47th Road toward Astoria.

The travel time from either of these landings is approximately 10 minutes.

BY BUS

From Queensboro Plaza:

Take stairway down north side to corner of Crescent and Bridge Plaza North.

Take the Q102 Queens Surface bus to Roosevelt Island.

Exit at the West Loop Rd bus stop, located at the Northwest corner of the campus.

On Roosevelt Island

RIOC RED BUS

The RIOC Red Bus provides bus service around Roosevelt Island; it makes all local stops every fifteen minutes from 5:45 AM until 2:30 AM every day.

A Red Bus Rush Hour Service runs on weekdays, 7:00 AM – 10:00 AM & 3:00 PM – 8:00 PM, during which buses will run approximately every 8 minutes.

There is no fare to ride the Red Bus.

Taking the bus from the Campus to Motorgate Parking Garage takes approximately 12 minutes.

Board the bus from the West Loop Rd stop, and take the bus Northbound to Motorgate. The bus stops directly in front of the parking garage.

From Motorgate to Cornell Tech, board a Southbound bus across the street from Motorgate and exit the bus at the West Loop Rd stop, located at the Northwest point of the Campus.

BY CAR

Event drop-off and collection is located at the corner of West Loop Road & North Loop Road, please utilize the address below for directions.

Please note, access to Roosevelt Island by vehicle is via the 36th Avenue Bridge in Queens.

Cornell Tech Campus

2 West Loop Road

New York, NY 10044

There is limited metered street parking available at both the Cornell Tech Campus & on Roosevelt Island.

Guests are encouraged to use public transportation.

Parking Facilities are available at Motorgate Garage: 688 Main Street, Roosevelt Island, NY 1004

*For information and hourly rates, visit: https://rioc.ny.gov/parking.htm

ADA ACCESSIBILITY

The Cornell Tech campus is in compliance with ADA, all of the buildings are easily accessbile.

SPECIAL THANKS TO ALL MEETING SPONSORS

2022 PRECEDE ANNUAL MEETING & BIOMARKER SUMMIT

DECEMBER 7-8, 2022